Dr Tania Webb

Qualifications: BSc (Hons), PhD

Research Interests

• Functional properties of oligomeric P2Y receptors.
• Receptor regulation of cellular function.
• Identification and characterisation of novel nucleotide receptors.

Recent Publications

1. Sherburn, R.E, Webb, T.E, Jenkins R.O, (2007) Detection of toxigenic bacteria in polyurethane foam from cot mattresses by polymerase chain reaction. Jpn J Infect Dis. 60:19-22.
2. Hainsworth, A.H, Nelson, R.M, Lambert, D.G, Green, A.R, Webb, T.E, (2006) Glutamate receptor-mediated inhibition of L-glutamate efflux from cerebral cortex in vitro. Brain Res. 1114:36-40.
3. Hainsworth, A.H, Bermpohl, D, Webb, T.E, Darwish, R, Fiskum, G, Qiu, J, McCarthy, D, Moskowitz, MA, Whalen, MJ, (2005) Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J Cereb Blood Flow Metab. 25:1030-40.
4. Agboh, K.C, Webb, T.E, Evans, R.J, Ennion, S.J, (2004) Functional characterization of a P2X receptor from Schistosoma mansoni. J Biol Chem. 279:41650-7.
5. Dixon, C.J, Hall, J.F, Webb, T.E, Boarder, M.R, (2004) Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate. J Pharmacol Exp Ther. 2004 311:334-41.
6. Bennett G.C, Ford A.P, Smith J.A, Emmett C.J, Webb T.E, Boarder, M.R., (2003) P2Y receptor regulation of cultured rat cerebral cortical cells: calcium responses and mRNA expression in neurons and glia. Br J Pharmacol. 139:279-88.
7. White, P.J, Webb, T.E, Boarder, M.R, (2003). Characterisation of a Ca2+ response to both UTP and ATP at human P2Y11 receptors: evidence for agonist-specific signalling. Molecular Pharmacology 63:1356-63.
8. Sak, K, Webb, T.E, (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Archives of Biochemistry and Biophysics, 397:131-6.

Projects

• Functional consequences of P2Y receptor dimerisation, BBSRC 3 year project grant.
• Characterisation of the transcriptional start sites and promoters of P2Y receptors, Wellcome Trust Vacation Scholarship.
• An evaluation of cot mattresses and their covers as reservoirs of toxigenic bacteria, Scottish Cot Death Trust, 2 year project grant.

Esteem/Professional Contribution

• Member of Biochemical Society.
• Member of the British Neuroscience Association.
• External examiner for PhD viva voce examinations.